Prof. (Dr) Rajendra Prasad
Dean Faculty of Science Engineering and Technology, Director AIB, AIISH
Faculty of Science Engineering And Technology

Amity University Haryana, Amity Education Valley, Pachgaon, Manesar, Gurgaon, Haryana 122413

Ph. D (Biochemistry), Agra University, 1970
M.Sc (Biochemistry), Lucknow University, 1967
B.Sc (Biology), Lucknow University, 1965

50 Years

Clinical resistance to Antifungal Mechanism
Regulation of resistances new Antifungal molecular mycology.


1. Yeast ATP-Binding Cassette Transporters Conferring Multidrug Resistance, Prasad R and Andre Goffeau Annual reviews of Microbiology,66,39-63(2012)

2. Rationally designed transmembrane peptide mimics of the multidrug transporter protein Cdr1 act as antagonists to selectively block drug efflux and chemosensitize azole-resistant clinical isolates of Candida albicans,Indresh Kumar Maurya,Chaitanya Kumar Thota,Sachin Dev Verma,Jyotsna Sharma,Manpreet Kaur Rawal,Balaguru Ravikumar,Shoban Sen,Neeraj Chauhan,Andrew M. Lynn4, Virander Singh Chauhan and Prasad R Journal of Biological Chemistry JBC Paper of the week, 288, 16775–16787 (2013).

3. Insight into pleiotropic drug resistance ATP-binding cassette pump drug transport through mutagenesis of Cdr1p transmembrane domains. Manpreet Kaur Rawal, Mohammad Firoz Khan, Khyati Kapoor, Neha Goyal, Sobhan Sen, Ajay Kumar Saxena, Andrew M. Lynn, Joel D. A. Tyndall, Brian C. Monk, Richard D. Cannon, Sneha Sudha Komath, and Prasad R J Biol Chem. 288:24480-93 (2013)

4. Mutational Analysis of Intracellular Loops Identify Cross Talk with Nucleotide Binding Domains of Yeast ABC Transporter Cdr1p. Abdul Haseeb Shah, Manpreet Kaur Rawal, Sanjiveeni Dhamgaye, Sneha Sudha Komath, Ajay Kumar Saxena, and Prasad R.,Science Reports,5,11211. (2015)

5. The ABCs of Candida albicans multidrug transporter Cdr1,Prasad R, Banerjee A, Khandelwal NK, Dhamgaye S. Eukaryotic Cell. 14,(12):1154-1164,(2015).

6. Azole resistance in a Candida albicans mutant lacking the ABC transporter CDR6/ROA1 depends on TOR signaling ; Khandelwal NK, Chauhan N, Sarkar P, Esquivel BD, Coccetti P, Singh A, Coste AT, Gupta M, Sanglard D, White TC, Chauvel M, d'Enfert C, Chattopadhyay A, Gaur NA, Mondal AK, Rajendra Prasad.; J Biol Chem. Jan 12;293(2):412-432. (2018) Cover page

7. Molecular basis of substrate polyspecificity of the Candid albicans Mdr1p multidrug/H+ antiporter. Archana K Redhu; Atanu Banerjee, Abdul H Shah; Alexis Moreno, Manpreet K Rawal,Remya Nair,Pierre Falson, Prasad R. J Mol Biol 430(5):682-694, (2018)

8. Vacuolar sequestration of azoles: A novel strategy of azole antifungal resistance conserved across pathogenic and non-pathogenic yeast. Khandelwal Nitesh,Wasi Mohd,Nair, Remya,Gupta Meghna, Mondal Alok Gaur Naseem, Prasad R. Antimicrobial Agent and Chemotherapy doi:10.1128/aac.(63) 01347-18 (2019).

9. Inventory of ABC proteins and their putative role in salt and drug tolerance in Debaryomyces hansenii. Prasad R,Mohd,Wasi,Nitesh K, Khandelwal,Poonam Vishwakarma,Andrew M Lynn, Alok K Mondal. Fungal Genetics and Biology. 15;676:227-242. doi: 10.1016/j.gene.2018.07.029. (2018) .

10. Phosphatidylserine decarboxylase governs plasma membrane fluidity and impacts drug susceptibilities of Candida albicans cells. Prasad R, Nitesh K Khandelwal, Parijat Sarkar, Naseem A Gaur, Amitabha Chattopadhyay. BBA – Biomembranes. S0005-2736(18)30158-5 (2018).
Clinical resistance to Antifungal Mechanism
Regulation of resistances new Antifungal molecular mycology.
Former Vice President, Indian National Science Academy
Former Pro Vice Chancellor, JNU
Former Dean, School Of Life Sciences
Founder Chairperson, Special Center Of Molecular Medicine
Vice President, Translational Society Of India
Research Ambassador, DAAD, Germany
Co-ordinator, Focal Points, Horizon 2020, European Commission
Dean, Faculty of Science,Engineering and Technology
Director, Amity Institute of Integrative Sciences and Health
Director, Amity Institute of Biotechnology
Royal Society Commonwealth Bursary
Alexander von Humboldt-Stiftung Fellowship
Wellcome Foundation
Biotechnology overseas Fellowship
Mercator Professorship at University of Bonn
Centre of Excellence, DBT
BSR-UGC award

Member, American Society of Microbiology, USA
Member, Society of Microbiology, UK
Member, American Association for the Advancement of Science
Member, International Society of Human and Animal Mycology
Member, Yeast Group, India.
Member, Association of Microbiologists of India
Member, Society for Indian Human and Animal Mycologists Society of Biological Chemists (India)
Member, Governing Body, Ambedkar Biomedical Center, DU
Visitor’s nominee, Jammu University
Elected Fellow , Indian Academy of Sciences
Elected Fellow, National Academy of Sciences
Elected Fellow, Indian National Science Academy
National Contact Point, European commission
Research Ambassador, Germany
International Yeast Commissioner
Vice President, INSA

Ongoing Projects:

1. Insight into the mechanism of drug transport mediated by multidrug transporters of Candida .
Funding Agency: DBT

2. Novel Potential Antifungal drugs active against multidrug resistant yeasts from the Candida genes.
Funding Agency: Indo-Polish (DST)

3. Alternate splicing in clinical drug resistance in pathogenic Candida
Funding Agency: SERB-DST

4. Combating Topical and Medical Device Related Multidrug Resistant Fungal Infections Using Molecularly Engineered Anti-Fungal Hydrogels
Funding Agency: DBT

5. Mechanism, evolution and pharmacology of multidrug resistance in the emerging fungal pathogen Candida auris among Indian cohort of patients
Funding Agency: ICMR

6. Unraveling the links between bioenergetics constraints, cell wall integrity, and multidrug resistance in fungi
Funding Agency: DST - RFBR

7. Study of in-depth genetic heterogeneity with respect to resistome and compensatory adaption of MDR Mtb clinical strains inside BM- Mesenchymal stem cells circulating in the North-East
Funding Agency: DBT
Faculty of Science Engineering And Technology
Amity University Haryana, Amity Education Valley, Pachgaon, Manesar, Gurgaon, Haryana 122413