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Qualifications
Ph.D.
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Experience
2025-Till Date: Assistant Professor-II
2019-2025: Postdoctoral Fellow, University of Connecticut (Uconn) Health Center, Dept of Neuroscience, Farmington, CT, USA.
2018-2019: IRTA Sponsored Postdoctoral Fellow, NICHD- National Institute of Health (NIH), Bethesda, MD, USA.
2015-2017: SRF, ICMR, CSIR- Central Drug Research Institute (CDRI), Lucknow, India.
2012-2015: JRF, ICMR, CSIR- Central Drug Research Institute (CDRI), Lucknow, India.
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Current Courses Taught
Neuro-109: Basic Molecular Biology and Neurogenetics.
Neuro-628: Molecular Biology of Neuron.
Neuro-409: Advanced Cellular and Molecular Biology.
Neuro-325: Behavioral and Social Neurobiology.
Neuro-312: Neuroethology
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Research Interests
Our research aims to decipher the molecular and cellular mechanisms that regulate brain development, neural stem cell function, and neurodegeneration. We investigate how disruptions in key signaling pathways, particularly Wnt signaling, contribute to dopaminergic neuron loss and impaired neurogenesis in neurodegenerative conditions. By integrating genetic and pharmacological approaches, we explore strategies to restore neuronal function and enhance brain repair.
In parallel, we study the genetic basis of neurodevelopmental disorders, focusing on how mutations in critical regulators of stem cell dynamics influence brain size, cortical organization, and neural circuit balance. Using advanced systems such as human stem cell–derived organoids and genetically engineered models, we examine how specific variants alter neurogenesis and contribute to conditions such as microcephaly and autism.
Our approach combines genome editing, high-resolution imaging, proteomics, RNA-sequencing, animal behavior and functional neuroscience techniques to uncover complex signaling networks. Through an interdisciplinary framework, we aim to bridge fundamental discoveries with translational applications, ultimately contributing to the development of targeted therapies for neurological disorders. Students in the lab gain hands-on experience with modern experimental approaches and are encouraged to think critically, ask questions, and actively participate in discovery-driven research. Full list of Publication- https://scholar.google.com/citations?user=-ukYXDwAAAAJ&hl=en&oi=ao
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Teaching Interests
Cellular and Molecular Biology, Neurobiology, Developmental Biology and Disease modelling.
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Publications
20
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Projects
1
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Professional Affiliations
Society for Neuroscience (SFN)
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Professional Activities
- Permanent reviewer board member of “Biomolecules” journal (Since 2021).
- Invited reviewer of Biomedicine, Neurochemistry International, International Journal of Molecular Sciences, Molecules and Brain Sciences.
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Other Achievements
- May 2025: Received Outstanding Scientific Presentation Award at Uconn Health Neuroscience Retreat 2025, held at Jackson Laboratory, Farmington, CT, USA.
- July 2022: Received International travel grant from Uconn Health Center, CT, USA.
- April 2018: Sponsored Intramural Research training award (IRTA), National Institutes of Health (NIH), Federal Government of USA, Bethesda, MD, USA.
- February 2018: First author Incentive award for best paper of the year of CSIR-CDRI 2018 (Axin- 2 knockdown promotes mitochondrial biogenesis and dopaminergic neurogenesis by regulating Wnt/ß- catenin signaling in rat model of Parkinson's disease, Free Radic Biol Med.).
- March 2018: Research article highlighted in international magazine “GSK-3 beta: a therapeutic target for Parkinson’s disease” Sonu Singh, Akanksha Mishra, Shubha Shukla, ATLAS OF SCIENCE, March 11, 2018. https://atlasofscience.org/gsk-3-beta-a-therapeutic-target-for-parkinsons-disease/
- 2012-2017: Received ICMR- Junior Research fellowship (JRF) for Ph.D.
- 2011: Qualified and secured all India Rank - 30th in the ICMR – Junior Research Fellowship Exam
- 2010: Secured I rank in master’s degree in Biomedical Sciences, Bundelkhand University, Jhansi, India.
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Contact Information
Amity Institute of Neuropsychology and Neurosciences (AINN)
Amity University, Sec 125, Block-J1, 2nd Floor, Room 221A, Noida, UP. Email: ssingh72@amity.edu
