The major focus has been in developing algorithm to resolve the problems in Genomics and transcriptomics focused on finding alternative splicing and its role in diseases, aging underlying in different organism and species. The group is also interested in understanding structural biology/system biology of several proteins using Molecular dynamics and omics data.The group also have a keen interest in applying data science technique such as deep learning and artificial intelligence to genomics and proteomics data.
Publications:
1. Multiple transcription factors co-regulate the Mycobacterium tuberculosis adaptation, response to Vitamin C, Malobi Nandi, Kriti Sikri, Neha Chaudhary, Shekhar Chintamani Mande, Ravi Datta Sharma & Jaya Sivaswami Tyagi, BMC Genomics 20, Article number: 887(2019),
2. A Localized Chimeric Hydrogel Therapy Combats Tumor Progression through Alteration of Sphingolipid Metabolism, Sanjay Pal, Nihal Medatwal, Sandeep Kumar, Animesh Kar,Varsha Komalla,Prabhu Srinivas Yavvari, Deepakkumar Mishra, Zaigham Abbas Rizvi, Shiv Nandan, Dipankar Malakar,Manoj Pillai,Amit Awasthi, Prasenjit Das,Ravi Datta sharma, Aasheesh Srivastava, Sagar Sengupta, Ujjaini Dasgupta, and Avinash Bajaj, ACS Cent. Sci. 2019, 5, 10, 1648-1662, DOI: 10.1021/acscentsci.9b00551, 2019
3. Aberrant splicing of BAF45d in gliomas: a link between splicing regulation and transcription, Guillermo Aldave, Marisol Gonzalez-Huarriz,Angel Rubio, Juan Pablo Romero, Datta Ravi, Bele´n Min~ana, Mar Cuadrado-Tejedor, Ana Garci´a- Osta, Roeland Verhaak, Enric Xipell, Naiara Martinez-Ve´lez, Arlet Acanda de la Rocha, Montserrat Puigdelloses, Marc Garci´a-Moure, Miguel Marigil, Jaime Ga´llego Pe´rez-Larraya, Oskar Mari´n-Bejar, Maite Huarte, Maria Stella Carro, Roberto Ferrarese, Cristobal Belda-Iniesta, Angel Ayuso, Ricardo Prat-Aci´n, Fernando Pastor, Ricardo Di´ez- Valle, Sonia Tejada, and Marta M. Alonso, Neuro-Oncology (2018), Volume 20, Issue 7, July 2018, Pages 930–941 DOI:10.1093/neuonc/noy007
4. Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity, Syed Tabrez, Ravi Sharma, Vaibhav Jain, Atif Siddiqui, and Arnab Mukhopadhyay, Nature Communications 8, Article number: 306 (2017), DOI:10.1038/s41467-017-00370-5
5. A LARGE-SCALE ANALYSIS OF ALTERNATIVE SPLICING REVEALS A KEY ROLE OF QKI IN LUNG CANCER, Fernando J de Miguel, Ravi D Sharma et al., Molecular Oncology, 2016, Nov;10(9):1437-1449. DOI:10.1016/j.molonc.2016.08.001,
6. Identification of alternative splicing events regulated by the oncogenic factor SRSF1 in lung cancer, Fernando J de Miguel*, Ravi D Sharma*, Mari´a J Pajares, Luis M Montuenga, Angel Rubio, Ruben Pio, Cancer Res (2014)74:1105-1115, DOI: 10.1158/0008-5472.CAN-13-1481) (* Joint first author).